The Division of Molecular Genetics at Columbia University Irving Medical Center in New York City is seeking a highly motivated Postdoctoral or Associate Research Scientist with expertise in stem cell biology and/or neurobiology to study the molecular genetics of novel obesity variants. Our work focuses on identifying rare genetic variants in children and adults with severe obesity by next generation sequencing, and its validation in patient-specific pluripotent stem cell derived neuronal models. The position will be under the direction of Dr. Thaker, a pediatric endocrinologist with expertise in computational biology, working in a vibrant research environment with cross-disciplinary expertise in a variety of in vivo and in vitro models.

KEY RESPONSIBILITIES

The eligible candidate will have exposure to cutting edge technologies including stem cell biology, single cell, and bulk RNA sequencing as well as clinical research in humans. We are a highly interactive and collaborative research team that works on creation and molecular characterization of mutation-specific human stem cell-derived hypothalamic neurons. The project will focus on identifying RNA expression profile of patient specific hypothalamic neurons intersecting with whole genome sequencing data to identify functional changes giving rise to extreme human phenotype. The scientist should have a strong interest in human stem cell biology and/or neurobiology. Previous expertise and/or interest in stem cell biology, next-generation sequencing technologies, and genomics is preferred, but not necessary. Motivation, strong interpersonal and communication skills including fluency in spoken and written English and excellence in scientific rigor is valued more than previous field of study. Advanced degree in Biological Sciences such as PhD or MD/PhD is required. The candidate will benefit from an interdisciplinary and collegial environment at Columbia and the vibrant and supportive atmosphere of a junior lab. Salary is competitive based on qualifications.

Qualifications

• Must have a doctorate degree (M.D. or Ph.D.)
• 2 – 3 years of postdoctoral training
• Consistently strong interpersonal skills and the ability to build and sustain effective working relationships with professionals in other disciplines;
• The ability to create a high-energy results-oriented work environment that encourages colleagues and staff to value each other’s contributions; and
• The ability to share and celebrate success with colleagues and staff.